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pentobarbital will lower the level or outcome of netupitant/palonosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; stay away from use in people who're chronically using a robust CYP3A4 inducerPhenobarbital continues to be demonstrated to shorten th